王鹏业

简介:
1982年毕业于山东大学。1988年于中国科学院物理研究所获博士学位。随后在中科院物理所工作至今。其间先后在意大利、法国、丹麦 、英国、美国进行访问研究。曾获杰青。现任中国科学院物理研究所研究员、博士生导师、国科大教授。

主要研究方向:
复杂系统和生物大分子的动力学研究。 包括的研究课题： 1.抗癌药物与DNA及活细胞的作用； 2.DNA与蛋白质的相互作用动力学； 3.生物分子马达的动力学； 4.利用量子点观察活细胞；5.单分子操纵和单细胞动态成像。

过去的主要工作及获得的成果:
早期从事光学研究，后来进入了物理学与生命科学交叉研究领域。1999年负责成立了“复杂系统和生物大分子的动力学”研究组。2001年负责成立了“软物质物理实验室”，并担任首届主任。研究了液晶和光学系统中的动力学行为和混沌现象。创立了一种控制非线性系统中斑图、时空混沌和螺旋波的有效方法 — 空间微扰法。模拟研究了行波微扰法对心脏动力学行为的控制作用。研究了可激系统中的动力学行为及斑图形成。研究了单分子DNA熔化、凝聚、DNA与组蛋白（histone）的相互作用、解旋酶（helicase）的动力学行为、生物分子马达（molecular motor）的动力学行为、抗癌药物顺铂（cisplatin）奥沙利铂（oxaliplatin）及反铂（transplatin）等与DNA的作用机理、单细胞中紫杉醇对表皮生长因子受体（EGFR）内吞运输的影响、量子点在活细胞内的扩散运动等。在《物理》，《物理学报》，《科学通报》，《Chinese Physics Letters》，《Chinese Physics B》，《Communications in Theoretical Physics》，《Physical Review Letters》，《Physical Review A, E》，《Optics Letters》，《Optics Communications》，《Applied Physics Letters》，《Molecular Crystals and Liquid Crystals》，《Journal of Chemical Physics》，《Journal of the American Chemical Society》，《Journal of Biological Chemistry》，《Journal of Theoretical Biology》，《Journal of Molecular Biology》，《Biochemistry》，《Nucleic Acids Research》，《Molecular Cell》，《Science China》，《Chinese Science Bulletin》，《iScience》，《Small》，《PNAS》，《Nature Communications》，《Nature》等物理学、化学、生物学及综合杂志上发表学术论文两百余篇。2000年获“国家杰出青年科学基金”。

代表性论文及专利:

部分已发表的学术论文： 

1. Chao Jiang, Hong-Yu Luo, Xinpeng Xu, Shuo-Xing Dou, Wei Li, Dongshi Guan, Fangfu Ye, Xiaosong Chen, Ming Guo, Peng-Ye Wang, Hui Li "Switch of cell migration modes orchestrated by changes of three-dimensional lamellipodium structure and intracellular diffusion" Nature Communications 14, 5166 (2023)
2. Jing-Wei Kong(孔敬伟), Shuo-Xing Dou(窦硕星), Wei Li(李伟), Hui Li(李辉), Peng-Ye Wang(王鹏业) "Parallel DNA G-Quadruplex Induced and Stabilized by Curaxin CBL0137" Chin. Phys. Lett. 40, 078701 (2023)
3. Anfeng Luo, Jingwei Kong, Jun Chen, Xue Xiao, Jie Lan, Xiaorong Li, Cuifang Liu, Peng-Ye Wang, Guohong Li, Wei Li, Ping Chen “H2B ubiquitination recruits FACT to maintain a stable altered nucleosome state for transcriptional activation” Nature Communications 14, 741 (2023)
4. Chao Jiang, Shuo-Xing Dou, Peng-Ye Wang, Hui Li “Quantifying transport dynamics with three-dimensional single-particle tracking in adherent cells” STAR Protocols 3, 101790 (2022)
5. Yao Wang, Yu-Ru Liu, Peng-Ye Wang, Ping Xie “Dynamics of cooperative transport by multiple kinesin motors and diffusing microtubule-associated proteins” Commun. Theor. Phys. 74, 105601 (2022)
6. Jian-Gang Wang, Xiao-Xuan Shi, Yu-Ru Liu, Peng-Ye Wang, Hong Chen, Ping Xie “Investigation of the structural and dynamic basis of kinesin dissociation from microtubule by atomistic molecular dynamics simulations” Chin. Phys. B 31, 058702 (2022)
7. Yi-Zhou Wang, Cuifang Liu, Jicheng Zhao, Juan Yu, Anfeng Luo, Xue Xiao, Shuo-Xing Dou, Lu Ma, Peng-Ye Wang, Ming Li, Guohong Li, Jianbin Yan, Ping Chen, Wei Li “H2A mono-ubiquitination differentiates FACT’s functions in nucleosome assembly and disassembly” Nucleic Acids Research 50, 833 (2022)
8. Chao Jiang, Mingcheng Yang, Wei Li, Shuo-Xing Dou, Peng-Ye Wang, Hui Li “Spatiotemporal three-dimensional transport dynamics of endocytic cargos and their physical regulations in cells” iScience 25, 104210 (2022)
9. Jing-Wen Yuan, Yu-Ning Zhang, Yu-Ru Liu, Wei Li, Shuo-Xing Dou, Yan Wei, Peng-Ye Wang, Hui Li “Diffusion Behaviors of Integrins in Single Cells Altered by Epithelial to Mesenchymal Transition” Small 18, 2106498 (2022)
10. Yuying Liu, Yao Wang, Pengye Wang, Ping Xie “Effect of Kinesin-5 Tail Domain on Motor Dynamics for Antiparallel Microtubule Sliding” Int. J. Mol. Sci. 22, 7857 (2021)
11. Ming-Li Zhang, Hui-Ying Ti, Peng-Ye Wang, Hui Li “Intracellular transport dynamics revealed by single-particle tracking” Biophys. Rep. 7, 413 (2021)
12. Yu-Ru Liu, Peng-Ye Wang, Wei Li, Ping Xie “Acceleration of DNA Replication of Klenow Fragment by Small Resisting Force” Chin. Phys. Lett. 38, 118701 (2021)
13. Xiao-Xuan Shi, Peng-Ye Wang, Hong Chen, Ping Xie “Studies of Conformational Changes of Tubulin Induced by Interaction with Kinesin Using Atomistic Molecular Dynamics Simulations” Int. J. Mol. Sci. 22, 6709 (2021)
14. Xinjia Zhao, Yuru Liu, Xiaoyu Chen, Zhuang Mi, Wei Li, Pengye Wang, Xinyan Shan, Xinghua Lu “Detection and Characterization of Single Cisplatin Adducts on DNA by Nanopore Sequencing” ACS Omega 6, 17027 (2021)
15. Linchang Dai, Xue Xiao, Lu Pan, Liuxin Shi, Ning Xu, Zhuqiang Zhang, Xiaoli Feng, Lu Ma, Shuoxing Dou, Pengye Wang, Bing Zhu, Wei Li, Zheng Zhou “Recognition of the inherently unstable H2A nucleosome by Swc2 is a major determinant for unidirectional H2A.Z exchange” Cell Reports 35, 109183 (2021)
16. Shuming Zhang, Xue Xiao, Jingwei Kong, Ke Lu, Shuo-Xing Dou, Peng-Ye Wang, Lu Ma, Yuru Liu, Guohong Li, Wei Li, Huidong Zhang “DNA polymerase Gp90 activities and regulations on strand displacement DNA synthesis revealed at single-molecule level” The FASEB Journal 35, e21607 (2021)
17. Yao Wang, Yu-Ying Liu, Jian Liang, Peng-Ye Wang, Ping Xie “Effects of rebinding rate and asymmetry in unbinding rate on cargo transport by multiple kinesin motors” Commun. Theor. Phys. 73, 015603 (2021)
18. Ke Lu, Cuifang Liu, Yinuo Liu, Anfeng Luo, Jun Chen, Zhichao Lei, Jingwei Kong, Xue Xiao, Shuming Zhang, Yi-Zhou Wang, Lu Ma, Shuo-Xing Dou, Peng-Ye Wang, Ming Li, Guohong Li, Wei Li, Ping Chen “Curaxin-Induced DNA Topology Alterations Trigger the Distinct Binding Response of CTCF and FACT at the Single-Molecule Level” Biochemistry 60, 494 (2021)
19. Chao Jiang, Bo Li, Shuo-Xing Dou, Peng-Ye Wang, Hui Li “Quasi-Two-Dimensional Diffusion in Adherent Cells Revealed by Three-Dimensional Single Quantum Dot Tracking” Chin. Phys. Lett. (Express Letter) 37, 078701 (2020)
20. Xue Xiao, Cuifang Liu, Yingxin Pei, Yi-Zhou Wang, Jingwei Kong, Ke Lu, Lu Ma, Shuo-Xing Dou, Peng-Ye Wang, Guohong Li, Ping Chen, Wei Li “Histone H2A Ubiquitination Reinforces Mechanical Stability and Asymmetry at the Single-Nucleosome Level” J. Am. Chem. Soc. 142, 3340 (2020)
21. Xiao-Xuan Shi, Si-Kao Guo, Peng-Ye Wang, Hong Chen, Ping Xie “All-atom molecular dynamics simulations reveal how kinesin transits from one-head-bound to two-heads-bound state” Proteins 88, 545 (2020)
22. Si-Kao Guo, Xiao-Xuan Shi, Peng-Ye Wang, Ping Xie “Run length distribution of dimerized kinesin-3 molecular motors: comparison with dimeric kinesin-1” Scientific Reports 9, 16973 (2019)
23. Si-Kao Guo, Xiao-Xuan Shi, Peng-Ye Wang, Ping Xie “Force dependence of unbinding rate of kinesin motor during its processive movement on microtubule” Biophys. Chem. 253, 106216 (2019)
24. Yi-Ben Fu, Si-Kao Guo, Peng-Ye Wang, Ping Xie “Dynamics of cooperative cargo transport by two elastically coupled kinesin motors” Eur. Phys. J. E42, 41 (2019)
25. Si-Kao Guo, Wei-Chi Wang, Peng-Ye Wang, Ping Xie “Force Dependence of Velocity and Run Length of Kinesin-1, Kinesin-2 and Kinesin-5 Family Molecular Motors” Molecules 24, 287 (2019)
26. Bo Li, Shuo-Xing Dou, Jing-Wen Yuan, Yu-Ru Liu, Wei Li, Fangfu Ye, Peng-Ye Wang, Hui Li “Intracellular transport is accelerated in early apoptotic cells” Proc Natl Acad Sci USA 115, 12118 (2018)
27. Xi-Ming Lu, Hui Li, Jing You, Wei Li, Peng-Ye Wang, Ming Li, Shuo-Xing Dou, Xu-Guang Xi “Folding Dynamics of Parallel and Antiparallel G‑Triplexes under the Influence of Proximal DNA” J. Phys. Chem. B 122, 9499 (2018)
28. Xue Xiao, Liping Dong, Yi-Zhou Wang, Peng-Ye Wang, Ming Li, Guohong Li, Ping Chen, Wei Li “Dissection of structural dynamics of chromatin fibers by single-molecule magnetic tweezers” Biophys Rep 4, 222 (2018)
29. Xiao-Xuan Shi, Yi-Ben Fu, Si-Kao Guo, Peng-Ye Wang, Hong Chen, Ping Xie “Investigating role of conformational changes of microtubule in regulating its binding affinity to kinesin by all-atom molecular dynamics simulation” Proteins 86, 1127 (2018)
30. Bo Li, Chao Ji, Xi-Ming Lu, Yu-Ru Liu, Wei Li, Shuo-Xing Dou, Hui Li, Peng-Ye Wang “Effect of Torsion on Cisplatin-Induced DNA Condensation” CHIN. PHYS. LETT. 35, 118701 (2018)
31. Si-Kao Guo, Xiao-Xuan Shi, Peng-Ye Wang, Ping Xie “Processivity of dimeric kinesin-1 molecular motors” FEBS Open Bio 8, 1332 (2018)
32. Ping Chen, Liping Dong, Mingli Hu, Yi-Zhou Wang, Xue Xiao, Zhongliang Zhao, Jie Yan, Peng-Ye Wang, Danny Reinberg, Ming Li, Wei Li, Guohong Li “Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level” Molecular Cell 71, 284 (2018)
33. Yi-Zhou Wang, Xi-Miao Hou, Hai-Peng Ju, Xue Xiao, Xu-Guang Xi, Shuo-Xing Dou, Peng-Ye Wang, Wei Li “Interaction between human telomeric G-quadruplexes characterized by single molecule magnetic tweezers” Chin. Phys. B 27, 068701 (2018)
34. Hui Li, Fangfu Ye, Jing-Yi Ren, Peng-Ye Wang, Li-Lin Du, Ji-Long Liu “Active transport of cytoophidia in Schizosaccharomyces pombe” FASEB J. 32, doi:10.1096/fj.201800045RR (2018)
35. Yi-Ben Fu, Yu-Ru Liu, Peng-Ye Wang, Ping Xie “A Revised Worm-Like Chain Model for Elasticity of Polypeptide Chains” J. Polym. Sci. Part B: Polym. Phys. 56, 297 (2018)
36. Jing You, Hui Li, Xi-Ming Lu, Wei Li, Peng-Ye Wang, Shuo-Xing Dou, Xu-Guang Xi “Effects of monovalent cations on folding kinetics of G-quadruplexes” Bioscience Reports 37, 20170771 (2017)
37. Si-Kao Guo, Peng-Ye Wang, Ping Xie “Dynamics of dimeric kinesins: Limping, effect of longitudinal force, effects of neck linker extension and mutation, and comparison between kinesin-1 and kinesin-2” International Journal of Biological Macromolecules 105, 1126 (2017)
38. Xi-Miao Hou, Yi-Ben Fu, Wen-Qiang Wu, Lei Wang, Fang-Yuan Teng, Ping Xie, Peng-Ye Wang, Xu-Guang Xi “Involvement of G-triplex and G-hairpin in the multi-pathway folding of human telomeric G-quadruplex” Nucleic Acids Research 45, 11401 (2017)
39. Zhan-Feng Wang, Yu-Ru Liu, Peng-Ye Wang, Ping Xie “An intermediate state of T7 RNA polymerase provides another pathway of nucleotide selection” Chin. Phys. B 26, 100203 (2017)
40. Lü Xi-Ming, Li Hui, You Jing, Li Wei, Wang Peng-Ye, Li Ming, Xi Xu-Guang, Dou Shuo-Xing “An optimization algorithm for single-molecule fluorescence resonance (smFRET) data processing” Acta Phys. Sin. 66, 118701 (2017)
41. Jing You, Ya-Nan Xu, Hui Li, Xi-Ming Lu, Wei Li, Peng-Ye Wang, Shuo-Xing Dou, Xu-Guang Xi “Helicase activity and substrate specificity of RecQ5beta” Chin. Phys. B 26, 068701 (2017)
42. Zhan-Feng Wang, Yi-Ben Fu, Peng-Ye Wang, Ping Xie “Dynamics of bridge helix bending in RNA polymerase II” Proteins 85, 614 (2017)
43. Zhan-Feng Wang, Zhi-Qiang Zhang, Yi-Ben Fu, Peng-Ye Wang, Ping Xie “Brownian ratchet mechanism of translocation in T7 RNA polymerase facilitated by a post-translocation energy bias arising from the conformational change of the enzyme” Chin. Phys. B 26, 030201 (2017)
44. Si-Kao Guo, Peng-Ye Wang, Ping Xie “A model of processive movement of dimeric kinesin” Journal of Theoretical Biology 414, 62 (2017)
45. Wei Li, Ping Chen, Juan Yu, Liping Dong, Dan Liang, Jianxun Feng, Jie Yan, Peng-Ye Wang, Qing Li, Zhiguo Zhang, Ming Li, Guohong Li “FACT Remodels the Tetranucleosomal Unit of Chromatin Fibers for Gene Transcription” Molecular Cell 64, 120 (2016)
46. Hai-Peng Ju, Yi-Zhou Wang, Jing You, Xi-Miao Hou, Xu-Guang Xi, Shuo-Xing Dou, Wei Li, Peng-Ye Wang “Folding Kinetics of Single Human Telomeric G‑Quadruplex Affected by Cisplatin” ACS Omega 1, 244 (2016)
47. Qing-Ji Shen, Hakimi Kassim, Yong Huang, Hui Li, Jing Zhang, Guang Li, Peng-Ye Wang, Jun Yan, Fangfu Ye, Ji-Long Liu “Filamentation of Metabolic Enzymes in Saccharomyces cerevisiae” Journal of Genetics and Genomics 43, 393 (2016)
48. Yi-Ben Fu, Zhan-Feng Wang, Peng-Ye Wang, Ping Xie “Optimal numbers of residues in linkers of DNA polymerase I, T7 primase and DNA polymerase IV” Sci. Rep. 6, 29125 (2016)
49. Yuru Liu, Ping Xie, Pengye Wang, Ming Li, Hui Li, Wei Li, Shuoxing Dou “A model for chromosome organization during the cell cycle in live E. coli” Sci. Rep. 5, 17133 (2015)
50. Li Wei, Wong Wei-Juan, Lim Ci-Ji, Ju Hai-Peng, Li Ming, Yan Jie, Wang Peng-Ye “Catch-bond behavior of DNA condensate under tension” Chin. Phys. B 24, 128704 (2015)
51. Hui Li, Shuo-Xing Dou, Yu-Ru Liu, Wei Li, Ping Xie, Wei-Chi Wang, Peng-Ye Wang “Mapping Intracellular Diffusion Distribution Using Single Quantum Dot Tracking: Compartmentalized Diffusion Defined by Endoplasmic Reticulum” J. Am. Chem. Soc. 137, 436 (2015)
52. Wei Li, Wei Juan Wong, Ci Ji Lim, Hai-Peng Ju, Ming Li, Jie Yan, Peng-Ye Wang “Complex kinetics of DNA condensation revealed through DNA twist tracing” Phys. Rev. E 92, 022707 (2015)
53. Zhi Zhou, Ying Hu, Xinyan Shan, Wei Li, Xuedong Bai, Pengye Wang, Xinghua Lu “Revealing Three Stages of DNA Cisplatin Reaction by a Solid-State Nanopore” Scientific Reports 5, 11868 (2015)
54. Hong-Yan Zhang, Yu-Ru Liu, Wei Li, Hui Li, Shuo-Xing Dou, Ping Xie, Wei-Chi Wang, Peng-Ye Wang “Condensations of single DNA molecules induced by heptaplatin and its chiral isomer” AIP Advances 4, 087128 (2014)
55. JU HaiPeng, ZHANG HongYan, LI Wei, WANG PengYe “Effects of oxaliplatin on DNA condensation” Science China 57, 2114 (2014)
56. ZHANG Hong-Yan, JI Chao, LIU Yu-Ru, LI Wei, LI Hui, DOU Shuo-Xing, WANG Wei-Chi, ZHANG Ling-Yun, XIE Ping, WANG Peng-Ye “Effects of pH on Oxaliplatin-Induced Condensation of Single DNA Molecules” Chin. Phys. Lett. 31, 028701 (2014)
57. Chao Ji, Lingyun Zhang, Shuoxing Dou, Pengye Wang “Local conformation transitions of linear DNA induced by cisplatin” Chin. Sci. Bull. 59, 3085 (2014)
58. Hong-Yan Zhang, Yu-Ru Liu, Chao Ji, Wei Li, Shuo-Xing Dou, Ping Xie, Wei-Chi Wang, Ling-Yun Zhang, Peng-Ye Wang “Oxaliplatin and its enantiomer induce different condensation dynamics of single DNA molecules” PLoS One 8, e71556 (2013)
59. Yu-Ru Liu, Chao Ji, Hong-Yan Zhang, Shuo-Xing Dou, Ping Xie, Wei-Chi Wang, Peng-Ye Wang “Transplatin enhances effect of cisplatin on both single DNA molecules and live tumor cells” Arch. Biochem. Biophys. 536, 12 (2013)
60. Wei Li, Xi-Miao Hou, Peng-Ye Wang, Xu-Guang Xi, Ming Li “Direct Measurement of Sequential Folding Pathway and Energy Landscape of Human Telomeric G-quadruplex Structures” J. Am. Chem. Soc. 135, 6423 (2013)
61. Chao Ji, Lingyun Zhang, Peng-Ye Wang “Quantitative analysis of the flexibility effect of cisplatin on circular DNA” Phys. Rev. E 88, 042703 (2013)
62. Wei Li, Peng-Ye Wang, Jie Yan, Ming Li “Impact of DNA Twist Accumulation on Progressive Helical Wrapping of Torsionally Constrained DNA” Phys. Rev. Lett. 109, 218102 (2012)
63. Hui Li, Zhao-Wen Duan, Ping Xie, Yu-Ru Liu, Wei-Chi Wang, Shuo-Xing Dou, Peng-Ye Wang “Effects of Paclitaxel on EGFR Endocytic Trafficking Revealed Using Quantum Dot Tracking in Single Cells” PLoS One 7, e45465 (2012)
64. Ya-Nan Xu, Nicolas Bazeille, Xiu-Yan Ding, Xi-Ming Lu, Peng-Ye Wang, Elisabeth Bugnard, Virginie Grondin, Shuo-Xing Dou, Xu Guang Xi “Multimeric BLM is dissociated upon ATP hydrolysis and functions as monomers in resolving DNA structures” Nucleic Acids Res. 40, 9802 (2012)
65. ZHANG ZhiQiang, LIU YuRu, XIE Ping, LI Wei, DOU ShuoXing, WANG PengYe “Studying the interaction between gyrase and DNA using magnetic tweezers” Chin. Sci. Bull. 57, 3560 (2012)
66. Zhao-Wen Duan, Ping Xie, Wei Li, Peng-Ye Wang “Are Coiled-Coils of Dimeric Kinesins Unwound during Their Walking on Microtubule?” PLoS One 7, e36071 (2012)
67. Wei Li, Zhi-Qiang Sun, Ping Xie, Shuo-Xing Dou, Wei-Chi Wang, Peng-Ye Wang “Elastic response and length change of single DNA molecules induced by a combination of cisplatin and transplatin” Phys. Rev. E 85, 021918 (2012)
68. Jun Huang, Hui Li, Wei Chen, Guo-Hua Lv, Xing-Quan Wang, Guo-Ping Zhang, Kostya Ostrikov, Peng-Ye Wang, Si-Ze Yang “Dielectric barrier discharge plasma in Ar/O2 promoting apoptosis behavior in A549 cancer cells” Appl. Phys. Lett. 99, 253701 (2011)
69. JI Chao, ZHANG Ling-Yun, HOU Xi-Miao, DOU Shuo-Xing, WANG Peng-Ye “Effect of Cisplatin on the Flexibility of Linear DNA” Chin. Phys. Lett. 28, 068702 (2011)
70. Bing-Yi Pan, Shuo-Xing Dou, Ye Yang, Ya-Nan Xu, Elisabeth Bugnard, Xiu-Yan Ding, Lingyun Zhang, Peng-Ye Wang, Ming Li, and Xu Guang Xi “Mutual Inhibition of RecQ Molecules in DNA Unwinding” J. Biol. Chem. 285, 15884 (2010)
71. SUN Zhi-Qiang, XIE Ping, LI Wei, WANG Peng-Ye “Spiking Regularity and Coherence in Complex Hodgkin–Huxley Neuron Networks” Chin. Phys. Lett. 27, 088702 (2010)
72. Ye Yang, Shuo-Xing Dou, Ya-Nan Xu, Nicolas Bazeille, Peng-Ye Wang, Pascal Rigolet, Hou-Qiang Xu and Xu Guang Xi “Kinetic Mechanism of DNA Unwinding by the BLM Helicase Core and Molecular Basis for Its Low Processivity” Biochemistry 49, 656 (2010)
73. Congxin Li, Xiaofang Chen, Pengye Wang and Weichi Wang “Circadian KaiC Phosphorylation: A Multi-Layer Network” PLoS Comput. Biol. 5, e1000568 (2009)
74. Bing-Yi Pan, Lingyun Zhang, Shuo-Xing Dou and Peng-Ye Wang “Forces-induced pinpoint denaturation of short DNA” Biochem. Biophys. Res. Commun. 388, 137 (2009)
75. Yi Wang, Yongjian Huang, Jiawei Wang, Chao Cheng, Weijiao Huang, Peilong Lu, Ya-Nan Xu, Pengye Wang, Nieng Yan and Yigong Shi “Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel” Nature 462, 467 (2009)
76. Xi-Miao Hou, Xing-Hua Zhang, Kong-Ji Wei, Chao Ji, Shuo-Xing Dou, Wei-Chi Wang, Ming Li and Peng-Ye Wang “Cisplatin induces loop structures and condensation of single DNA molecules” Nucleic Acids Res. 37, 1400 (2009)
77. Xi-Miao Hou, Wei Li, Shuo-Xing Dou, Ling-Yun Zhang, Ping Xie, Wei-Chi Wang and Peng-Ye Wang “Formation of DNA toroids inside confined droplets adsorbed on mica surfaces” Phys. Rev. E 79, 051912 (2009)
78. WANG Hong, DOU Shuo-Xing, WANG Peng-Ye “Monte Carlo Simulation on Coordinated Movement of Kinesin and Dynein Motors” Chin. Phys. Lett. 25, 321 (2008)
79. Xiao-fang Chen, Cong-xin Li, Peng-ye Wang, Ming Li, Wei-chi Wang “Dynamic simulation of the effect of calcium-release activated calcium channel on cytoplasmic Ca2+ oscillation” Biophysical Chemistry 136, 87 (2008)
80. Ye Yang, Shuo-Xing Dou, Hua Ren, Peng-Ye Wang, Xing-Dong Zhang, Min Qian, Bing-Yi Pan and Xu Guang Xi ”Evidence for a functional dimeric form of the PcrA helicase in DNA unwinding” Nucleic Acids Res. 36, 1976 (2008)
81. WANG Peng-Ye, LI Ming, WENG Yu-Xiang “Recent progress in biological soft matter research” Physics (WU LI) 37, 441 (2008)
82. Wei Li, Shuo-Xing Dou, Ping Xie, and Peng-Ye Wang “Brownian dynamics simulation of the effect of histone modification on nucleosome structure” Phys. Rev. E 75, 051915 (2007)
83. Rong-Bing Guo, Pascal Rigolet, Hua Ren, Bo Zhang, Xing-Dong Zhang, Shuo-Xing Dou, Peng-Ye Wang, Mounira Amor-Gueret and Xu Guang Xi “Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein” Nucleic Acids Res. 35 6297 (2007)
84. Yong Zhang, Xin Zhao, Peng-Ye Wang “Molecular dynamics study of the fibril elongation of the prion protein fragment PrP106–126” J. Theor. Biol. 245, 238 (2007)
85. Ping Xie, Shuo-Xing Dou, Peng-Ye Wang “Limping of homodimeric kinesin motors” J. Mol. Biol. 366, 976 (2007)
86. Kai-Ge Wang, Shuanglin Yue, Lei Wang, Aizi Jin, Changzhi Gu, Peng-Ye Wang, Yuchun Feng, Yuncheng Wang, Hanben Niu “Manipulating DNA molecules in nanofluidic channels” Microfluid Nanofluid 2, 85 (2006)
87. Jun Qian, Ping Xie, Shuo-Xing Dou, Peng-Ye Wang “A model for biased diffusion of collagenase along collagen fibrils” J. Theor. Biol. 243, 322 (2006)
88. Ping Xie, Shuo-Xing Dou, Peng-Ye Wang “Model for kinetics of myosin-V molecular motors” Biophysical Chemistry 120, 225 (2006)
89. Wei Li, Shuo-Xing Dou, Ping Xie, Peng-Ye Wang “Brownian dynamics simulation of directional sliding of histone octamers caused by DNA bending” Phys. Rev. E 73, 051909 (2006)
90. Xing-Dong Zhang, Shuo-Xing Dou, Ping Xie, Jin-Shan Hu, Peng-Ye Wang, Xu Guang Xi “E. coli RecQ is a rapid, efficient and monomeric helicase” J. Biol. Chem. 281, 12655 (2006)
91. Wei Li, Shuo-Xing Dou, Peng-Ye Wang “The histone octamer influences the wrapping direction of DNA on it: Brownian dynamics simulation of the nucleosome chirality” J. Theor. Biol. 235, 365 (2005)
92. Qian Jun, Xie Ping, Dou Shuo-Xing, Wang Peng-Ye “Numerical study of the coupling between F0 with varied numbers of c-subunits and F1 in an ATP synthase” Chin. Phys. 14, 2214 (2005)
93. Xie Ping, Dou Shuo-Xing, Wang Peng-Ye “A model for processivity of molecular motors” Chin. Phys. 13, 1569 (2004)
94. Yu-Ying Liu, Peng-Ye Wang, Shuo-Xing Dou, Wei-Chi Wang, Ping Xie, Hua-Wei Yin, Xing-Dong Zhang, Xu Guang Xi “Ionic effect on combing of single DNA molecules and observation of their force-induced melting by fluorescence microscopy” J. Chem. Phys. 121, 4302 (2004)
95. Wei Li, Shuo-Xing Dou, Peng-Ye Wang “Brownian dynamics simulation of nucleosome formation and disruption under stretching” J. Theor. Biol. 230, 375 (2004)
96. Wang Peng-Ye, Xie Ping, Yin Hua-Wei “Control of spiral waves and turbulent states in a cardiac model by travelling-wave perturbations” Chin. Phys. 12, 674 (2003)
97. Peng-Ye Wang, Weiping Lu, Dejin Yu, Robert G. Harrison “Excitability and pattern formation in a liquid crystal Fabry–Pérot interferometer” Optics Communications 189, 127 (2001)
98. Peng-Ye Wang, Ping Xie “Eliminating spatiotemporal chaos and spiral waves by weak spatial perturbations” Phys. Rev. E 61, 5120 (2000)
99. Peng-Ye Wang, M. Saffman “Selecting optical patterns with spatial phase modulation” Optics Letters 24, 1118 (1999)
100. Peng-Ye Wang “First-Passage-Time Distributions of the Freedericksz Transition in Nematic Liquid Crystals” Molecular Crystals and Liquid Crystals 319, 1 (1998)
101. M. Ciofini, A. Labate, R. Meucci, Peng-Ye Wang “Experimental evidence of selection and stabilization of spatial patterns in a CO2 laser by means of spatial perturbations” Optics Communications 154, 307 (1998)
102. Peng-Ye Wang, Ping Xie, Jian-Hua Dai, Hong-Jun Zhang “Stabilization, Selection, and Tracking of Unstable Patterns by Weak Spatial Perturbations” Phys. Rev. Lett. 80, 4669 (1998)
103. Peng-Ye Wang “Transient Statistics of the Freedericksz Transition in Nematic Liquid Crystals” Molecular Crystals and Liquid Crystals 302, 397 (1997)
104. J. C. Garreau, Peng-Ye Wang, P. Glorieux “Bit correlation and memory effects in high-speed pump modulation of a fiber laser” IEEE Journal of Quantum Electronics 30, 1058 (1994)
105. M. Ciofini, A. Lapucci, R. Meucci, Peng-ye Wang, F. T. Arecchi “Two-peak passage-time distributions in transient CO2 lasers near threshold” Phys. Rev A 46, 5874 (1992)
106. R.Meucci, M.Ciofini, Peng-ye Wang “Analysis of the dynamical behavior of a Q-switched CO2 laser: the linear and the nonlinear regime” Optics Communications 91, 444 (1992)
107. R. Meucci, Peng-ye Wang, A. Lapucci “Dynamic behavior of the optogalvanic effect in a CO2 laser” Optics Letters 16, 1040 (1991)
108. Peng-ye Wang, A. Lapucci, R. Meucci, F.T. Arecchi “Onset of subcritical bifurcation in a CO2 laser with feedback” Optics Communications 80, 42 (1990)
109. Peng-ye Wang, Jian-hua Dai, Hong-jun Zhang “Optically induced frequency locking of a nematic liquid crystal in a Fabry-Perot interferometer” Phys. Rev. A 41, 3250 (1990)
110. Peng-ye Wang, Hong-jun Zhang, Jian-hua Dai “Laser-heating-induced self-phase modulation, phase transition, and bistability in nematic liquid crystals” Optics Letters 13, 479 (1988)
111. Peng-ye Wang, Hong-jun Zhang, Jian-hua Dai “Feedback-induced first-order Freedericksz transition in a nematic film” Optics Letters 12, 654 (1987)
112. WANG PENG-YE, ZHANG HONG-JUN, DAI JIAN-HUA “CRITICAL PHENOMENA IN OPTICAL BISTABILITY AND CHAOS” Acta Phys. Sin. 34, 1233 (1985)
113. WANG PENG-YE, DAI JIAN-HUA, ZHANG HONG-JUN “BIFURCATION, CHAOS AND TRANSIENT BEHAVIOR IN LIQUID CRYSTAL HYBRID OPTICAL BISTABLE DEVICES” Acta Phys. Sin. 34, 581 (1985)

目前的研究课题及展望:
上述方向是国际上的研究前沿，具有巨大的发展潜力和广泛的国际合作基础。实验室目前具有高精度荧光显微镜（包括镜下细胞培养系统）、高灵敏成像设备、单分子力谱设备（磁镊）、快速停流设备、原子力显微镜、各种先进的生化设备等。另外还有并行计算服务器。装备水平居世界前列。

培养研究生情况:
已毕业博士研究生二十多名。

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