陆颖

简介:
2004年于北京工业大学获得学士学位。
2010年于中国科学院物理研究所获理学博士学位（导师：李明研究员）。
2010年7月至今中国科学院物理研究所软物质物理重点实验室工作。
2020年获国家自然科学基金委优秀青年基金。 
 

主要研究方向:
主要从事物理学与生命科学交叉领域的研究，致力于用超高精度单分子荧光技术研究生物分子的运行机理。

过去的主要工作及获得的成果:
1.发展了精度达到亚纳米的表面诱导荧光衰减方法，一举突破膜蛋白位置测量的技术瓶颈，可实时测量膜蛋白插膜的动力学。运用该方法，解析了多肽的跨膜过程。
2.发展了基于囊泡的荧光淬灭方法，此技术可以用于更为精确地研究接近真实生命过程的蛋白与膜相互作用的动态过程。
3.发展了DNA弓方法，用于提高单分子荧光共振能量转移的精度，应用该方法研究核酸酶，可以精确测量单个水解能量所驱动的分子马达在核酸上的运动，极大提高分子马达的研究能力。

代表性论文及专利:

(1) Yang, Chenguang; He, Xiaolong; Wang, Hao; Lin, Zhao; Hou, Wenqing; Lu, Ying; Hu, Shuxin; Li, Ming; Single-Molecule Monitoring of Membrane Association of the Necroptosis Executioner MLKL with Discernible Anchoring and Insertion Dynamics, Nano Letters, 2023, 23(2): 4770-4777
(2) Li, Jinghua; Ma, Jianbing; Kumar, Vikash; Fu, Hang; Xu, Chunhua; Wang, Shuang; Jia, Qi; Fan, Qinkai; Xi, Xu-Guang; Li, Ming; Liu, Haiguang; Lu, Ying ; Identification of flexible Pif1–DNA interactions and their impacts on enzymatic activities, Nucleic Acids Research , 2022, 50(12): 7002-7012
(3) Lu, Ying; Ma, Jianbing; Li, Ming ; Chapter 3, Single-Molecule Biosensing by Fluorescence Resonance Energy Transfer, Jenny Stanford Publishing, 2022 
(4) Ma, Jianbing; Xu, Chunhua Xu; Li, Jinghua; Hou, Xi-Miao; Da, Lin-Tai; Jia, Qi; Huang, Xingyuan; Yu, Jin; Xi, Xuguang; Lu, Ying; Li, Ming ; RQC helical hairpin in Bloom's syndrome helicase regulates DNA unwinding by dynamically intercepting nascent nucleotides, iScience , 2022, 25(1): 103606 
(5) Jiang, Xin; Yang, Chenguang; Qiu, Jie; Ma, Dongfei; Xu, Chen; Hu, Shuxin; Han, Weijing; Yuan, Bing; Lu, Ying ; Nanomolar LL-37 induces permeability of a biomimetic mitochondrial membrane, Nanoscale , 2022, 14: 15654-15660 
(6) Wang, Shuang; Lu, Ying; Li, Ming ; Single-molecular methodologies for the physical biology of protein machines, Chinese Physics B , 2022, 31: 28702 
(7) Hou, Wenqing; Ma, Dongfei; He, Xiaolong; Han, Weijing; Ma, Jianbing; Wang, Hao; Xu, Chunhua; Xie, Ruipei; Fan, Qihui; Ye, Fangfu; Hu, Shuxin; Li, Ming; Lu, Ying ; Subnanometer-Precision Measurements of Transmembrane Motions of Biomolecules in Plasma Membranes Using Quenchers in Extracellular Environment, Nano Letters , 2021, 21(1): 485-491
(8) Fan, Qihui; Zheng, Yu; Wang, Xiaochen; Xie, Ruipei; Ding, Yu; Wang, Boyi; Yu, Xiaoyu; Lu, Ying; Liu, Liyu; Li, Yunliang; Li, Ming; Zhao, Yuanjin; Jiao, Yang; Ye, Fangfu ; Dynamically Re-Organized Collagen Fiber Bundles Transmit Mechanical Signals and Induce Strongly Correlated Cell Migration and Self-Organization, Angewandte Chemie International Edition , 2021, 60(21): 11858-11867 
(9) Ma, Jian-Bing; Chen, Ze; Xu, Chun-Hua; Huang, Xing-Yuan; Jia, Qi; Zou, Zhen-Yu; Mi, Chen-Yang; Ma, Dong-Fei; Lu, Ying; Zhang, Hui-Dong; Li, Ming ; Dynamic structural insights into the molecular mechanism of DNA unwinding by the bacteriophage T7 helicase, Nucleic Acids Research , 2020, 48(6): 3156-3164 
(10) Huang, Xingyuan; Lu, Ying; Wang, Shuang; Sui, Mingyu; Li, Jinghua; Ma, Jianbing; Ma, Dongfei; Jia, Qi; Hu, Shuxin; Xu, Chunhua; Li, Ming ; Mismatch sensing by nucleofilament deciphers mechanism of RecA-mediated homologous recombination, Proceedings of the National Academy of Sciences of the United States of America , 2020, 117(34): 20549-20554 
(11) Ma, Dong-Fei; Xu, Chun-Hua; Hou, Wen-Qing; Zhao, Chun-Yu; Ma, Jian-Bing; Huang, Xing-Yuan; Jia, Qi; Ma, Lu; Diao, Jiajie; Liu, Cong; Li, Ming; Lu, Ying ; Detecting Single-Molecule Dynamics on Lipid Membranes with Quenchers-in-a-Liposome FRET, Angewandte Chemie International Edition , 2019, 58(17): 5577-5581
(12) Li, Meijing; Xia, Xian; Tian, Yuanyuan; Jia, Qi; Liu, Xiaoyu; Lu, Ying; Li, Ming; Li, Xueming; Chen, Zhucheng ; Mechanism of DNA translocation underlying chromatin remodelling by Snf2, Nature , 2019, 567(7748): 409-413 
(13) Zhang, Qian; Wen, Fengcai; Zhang, Siqi; Jin, Jiachuan; Bi, Lulu; Lu, Ying; Li, Ming; Xi, Xu-Guang; Huang, Xingxu; Shen, Bin; Sun, Bo ; The post-PAM interaction of RNA-guided spCas9 with DNA dictates its target binding and dissociation, Science Advances , 2019, 5(11): eaaw9807 
(14) Lin, Wenxia; Ma, Jianbing; Nong, Daguan; Xu, Chunhua; Zhang, Bo; Li, Jinghua; Jia, Qi; Dou, Shuoxing; Ye, Fangfu; Xi, Xuguang; Lu, Ying; Li, Ming ; Helicase Stepping Investigated with One-Nucleotide Resolution Fluorescence Resonance Energy Transfer, Physical Review Letters , 2017, 119(13): 138102 
(15) Li, Ying; Qian, Zhenyu; Ma, Li; Hu, Shuxin; Nong, Daguan; Xu, Chunhua; Ye, Fangfu; Lu, Ying; Wei, Guanghong; Li, Ming ; Single-molecule visualization of dynamic transitions of pore-forming peptides among multiple transmembrane positions, Nature Communications , 2016, 7: 12906 
(16) Li, Jing-Hua; Lin, Wen-Xia; Zhang, Bo; Nong, Da-Guan; Ju, Hai-Peng; Ma, Jian-Bing; Xu, Chun-Hua; Ye, Fang-Fu; Xi, Xu Guang; Li, Ming; Lu, Ying; Dou, Shuo-Xing ; Pif1 is a force-regulated helicase, Nucleic Acids Research , 2016, 44(9): 4330-4339 

目前的研究课题及展望:
1.研究离体和在体生物膜以及相关膜蛋白的动力学过程。
2.研究马达蛋白的动力学过程。

培养研究生情况:

拟每年招收研究生（硕博连读生或博士生）1-3名。

每年招聘博士后1-3名，具有生物物理、细胞生物学、分子生物学背景均可。

其他联系方式:

010-82648122

电话：
010-82648122

Email:
yinglu@iphy.ac.cn